Necrotizing enterocolitis
Updates to Article Attributes
Necrotising enterocolitis (NEC) is the most common gastrointestinal condition in premature neonates, and continues to have significant mortality and morbidity.
Epidemiology
NEC usually develops 2-3 days following birth, with 90% developing within the first 10 days of life 4. The incidence is inversely proportional to gestational age, with 90% occurring in premature infants. Its overall incidence is ~1 in 1000 births but is as high as 20% in low birth weight infants (<1500g) 5.
Clinical presentation
Presentation is often non-specific, and includes:
- poor feeding
- bile-stained vomitus
- abdominal distension
- blood-stained stools +/- explosive diarrhoea
- respiratory distress with acidosis
- features of generalised sepsis
Risk factors
- prematurity (50-80%) 4
- congenital heart disease
- perinatal asphyxia
- decreased umbilical flow in utero
Pathology
NEC is usually idiopathic and multi-factorial. A combination of ischaemic and infective aetiology with added contributive factors such as immature immunity have been proposed 1. Although a partially infective aetiology has also been proposed, no causitive organism has been isolated. Translocation of intestinal flora though immature mucosa has been postulated 5.
Inflammation starts from the mucosal surface and progresses to haemorrhagic and coagulative necrosis with the ensuing loss of mucosal integrity, transmural necrosis and perforation.
Although NEC can affect any part of the large or small bowel, the most common location is the terminal ileum. Other sites include caecum, right colon as well as less common areas such as stomach.
Radiographic features
Plain film
Supine abdominal x-rays are the mainstay of diagnosis. If NEC is suspected clinically, or there is concern on supine films, then an additional cross-table lateral or left-lateral decubitus film should be obtained 5:
- dilated bowel loops (often asymmetrical in distribution)
- loss of the normal polygynal gas shape
- bowel wall oedema with thumb printing
- pneumatosis intestinalis (intramural gas)
- portal venous gas
-
pneumoperitoneum secondary to perforation
- air on both sides of the bowel (Rigler sign)
- air outlining the falciform ligament (football sign)
- it is important to note that only 50-75% of patients with proven perforation will have visible free gas 5
Ultrasound
- bowel wall thickening
free fluid - alteration of vascular state
- hypervascular (viable but engorged in early stage)
- hypovascular (infarcted in later stage)
- intramural gas manifesting as
high echohyperechoic foci within the bowel wall - free fluid especially with echogenic debris is suspicious for perforation 5
Treatment and prognosis
NEC can be managed both medically and surgically and appropriate patient selection is essential in optimising outcome. A clinical staging system has been developed (see necrotising enterocolitis staging), with stage I and II receiving medical therapy and stage III undergoing surgery 8.
Medical management consists of supportive measures and cessation of oral feeding, along with broad spectrum antibiotics and gasticgastric aspiration 7.
Surgery is usually reserved for patients with evidence of perforation, and entails resection of clearly necrotic bowel and the creation of a proximal enterostomy 5-6. Other relative indications for surgery include portal venous gas, a fixed dilated loop on serial x-rays and abdominal wall erythema 7. Re-anastomosis is usually delayed until the infant has completely recovered.
Despite therapy, mortality remains significant, ranging between 9 and 28% 5. Furthermore ~20% of surviving patients will go on to develop stricture. These are more commonly in the large bowel (80%) and may result in bowel obstruction weeks andto months later 5, 8.
Differential diagnosis
In the correct clinical scenario the presence of gas within bowel wall has little differential.Conditions worth keeping in mind include 8:
-<p><strong>Necrotising enterocolitis (NEC)</strong> is the most common gastrointestinal condition in premature neonates, and continues to have significant mortality and morbidity.</p><h4>Epidemiology</h4><p>NEC usually develops 2-3 days following birth, with 90% developing within the first 10 days of life <sup>4</sup>. The incidence is inversely proportional to gestational age, with 90% occurring in premature infants. Its overall incidence is ~1 in 1000 births but is as high as 20% in low birth weight infants (<1500g) <sup>5</sup>.</p><h4>Clinical presentation</h4><p>Presentation is often non-specific, and includes:</p><ul>-<li>poor feeding </li>-<li>bile-stained vomitus</li>-<li>abdominal distension</li>-<li>blood-stained stools +/- explosive diarrhoea</li>-<li>respiratory distress with acidosis</li>-<li>features of generalised sepsis</li>-</ul><h5>Risk factors</h5><ul>-<li>prematurity (50-80%) <sup>4</sup>-</li>-<li><a href="/articles/congenital-heart-disease">congenital heart disease</a></li>-<li>perinatal asphyxia</li>-<li>decreased umbilical flow <em>in utero</em>-</li>-</ul><h4>Pathology</h4><p>NEC is usually idiopathic and multi-factorial. A combination of ischaemic and infective aetiology with added contributive factors such as immature immunity have been proposed <sup>1</sup>. Although a partially infective aetiology has also been proposed, no causitive organism has been isolated. Translocation of intestinal flora though immature mucosa has been postulated <sup>5</sup>.</p><p>Inflammation starts from the mucosal surface and progresses to haemorrhagic and coagulative necrosis with the ensuing loss of mucosal integrity, transmural necrosis and perforation.</p><p>Although NEC can affect any part of the large or small bowel, the most common location is the terminal <a href="/articles/ileum">ileum</a>. Other sites include <a href="/articles/caecum">caecum</a>, right colon as well as less common areas such as <a href="/articles/stomach">stomach</a>.</p><h4>Radiographic features</h4><h5>Plain film</h5><p>Supine abdominal x-rays are the mainstay of diagnosis. If NEC is suspected clinically, or there is concern on supine films, then an additional cross-table lateral or left-lateral decubitus film should be obtained <sup>5</sup>:</p><ul>-<li>dilated bowel loops (often asymmetrical in distribution)</li>-<li>loss of the normal polygynal gas shape</li>-<li>bowel wall oedema with <a href="/articles/thumbprinting">thumb printing</a>-</li>-<li>-<a href="/articles/pneumatosis-intestinalis">pneumatosis intestinalis</a> (<a href="/articles/intramural-gas">intramural gas</a>)</li>-<li><a href="/articles/portal_venous_gas">portal venous gas</a></li>-<li>-<a href="/articles/pneumoperitoneum">pneumoperitoneum</a> secondary to perforation<ul>-<li>air on both sides of the bowel (<a href="/articles/rigler-sign-1">Rigler sign</a>)</li>-<li>air outlining the falciform ligament (<a href="/articles/football-sign-2">football sign</a>)</li>-<li>it is important to note that only 50-75% of patients with proven perforation will have visible free gas <sup>5</sup>-</li>-</ul>-</li>-</ul><h5>Ultrasound</h5><ul>-<li>bowel wall thickening free fluid </li>-<li>alteration of vascular state<ul>-<li>hypervascular (viable but engorged in early stage)</li>-<li>hypovascular (infarcted in later stage)</li>-</ul>-</li>-<li>intramural gas manifesting as high echo foci within the bowel wall</li>-<li>free fluid especially with echogenic debris is suspicious for perforation <sup>5</sup>-</li>-</ul><h4>Treatment and prognosis</h4><p>NEC can be managed both medically and surgically and appropriate patient selection is essential in optimising outcome. A clinical staging system has been developed (see <a href="/articles/necrotising-enterocolitis-staging">necrotising enterocolitis staging</a>), with stage I and II receiving medical therapy and stage III undergoing surgery <sup>8</sup>.</p><p>Medical management consists of supportive measures and cessation of oral feeding, along with broad spectrum antibiotics and gastic aspiration <sup>7</sup>. </p><p>Surgery is usually reserved for patients with evidence of perforation, and entails resection of clearly necrotic bowel and the creation of a proximal enterostomy <sup>5-6</sup>. Other relative indications for surgery include <a href="/articles/portal_venous_gas">portal venous gas</a>, a fixed dilated loop on serial x-rays and abdominal wall erythema <sup>7</sup>. Re-anastomosis is usually delayed until the infant has completely recovered.</p><p>Despite therapy, mortality remains significant, ranging between 9 and 28% <sup>5</sup>. Furthermore ~20% of surviving patients will go on to develop stricture. These are more commonly in the <a href="/articles/large-intestine-1">large bowel</a> (80%) and may result in bowel obstruction weeks and months later <sup>5, 8</sup>.</p><h4>Differential diagnosis</h4><p>In the correct clinical scenario the presence of gas within bowel wall has little differential.<br>Conditions worth keeping in mind include <sup>8</sup>:</p><ul>-<li><a href="/articles/pneumatosis-coli">pneumatosis coli</a></li>-<li><a href="/articles/neonatal-appendicitis">neonatal appendicitis</a></li>-<li><a href="/articles/meconium-ileus">meconium ileus</a></li>-<li><a href="/articles/hirschsprung-disease">Hirschsprung disease</a></li>-<li><a href="/articles/infectious-enterocolitis">infectious enterocolitis</a></li>- +<p><strong>Necrotising enterocolitis (NEC)</strong> is the most common gastrointestinal condition in premature neonates, and continues to have significant mortality and morbidity.</p><h4>Epidemiology</h4><p>NEC usually develops 2-3 days following birth, with 90% developing within the first 10 days of life <sup>4</sup>. The incidence is inversely proportional to gestational age, with 90% occurring in premature infants. Its overall incidence is ~1 in 1000 births but is as high as 20% in low birth weight infants (<1500g) <sup>5</sup>.</p><h4>Clinical presentation</h4><p>Presentation is often non-specific, and includes:</p><ul>
- +<li>poor feeding </li>
- +<li>bile-stained vomitus</li>
- +<li>abdominal distension</li>
- +<li>blood-stained stools +/- explosive diarrhoea</li>
- +<li>respiratory distress with acidosis</li>
- +<li>features of generalised sepsis</li>
- +</ul><h5>Risk factors</h5><ul>
- +<li>prematurity (50-80%) <sup>4</sup>
- +</li>
- +<li><a href="/articles/congenital-heart-disease">congenital heart disease</a></li>
- +<li>perinatal asphyxia</li>
- +<li>decreased umbilical flow <em>in utero</em>
- +</li>
- +</ul><h4>Pathology</h4><p>NEC is usually idiopathic and multi-factorial. A combination of ischaemic and infective aetiology with added contributive factors such as immature immunity have been proposed <sup>1</sup>. Although a partially infective aetiology has also been proposed, no causitive organism has been isolated. Translocation of intestinal flora though immature mucosa has been postulated <sup>5</sup>.</p><p>Inflammation starts from the mucosal surface and progresses to haemorrhagic and coagulative necrosis with the ensuing loss of mucosal integrity, transmural necrosis and perforation.</p><p>Although NEC can affect any part of the large or small bowel, the most common location is the terminal <a href="/articles/ileum">ileum</a>. Other sites include <a href="/articles/caecum">caecum</a>, right colon as well as less common areas such as <a href="/articles/stomach">stomach</a>.</p><h4>Radiographic features</h4><h5>Plain film</h5><p>Supine abdominal x-rays are the mainstay of diagnosis. If NEC is suspected clinically, or there is concern on supine films, then an additional cross-table lateral or left-lateral decubitus film should be obtained <sup>5</sup>:</p><ul>
- +<li>dilated bowel loops (often asymmetrical in distribution)</li>
- +<li>loss of the normal polygynal gas shape</li>
- +<li>bowel wall oedema with <a href="/articles/thumbprinting">thumb printing</a>
- +</li>
- +<li>
- +<a href="/articles/pneumatosis-intestinalis">pneumatosis intestinalis</a> (<a href="/articles/intramural-gas">intramural gas</a>)</li>
- +<li><a href="/articles/portal-venous-gas">portal venous gas</a></li>
- +<li>
- +<a href="/articles/pneumoperitoneum">pneumoperitoneum</a> secondary to perforation<ul>
- +<li>air on both sides of the bowel (<a href="/articles/rigler-sign-1">Rigler sign</a>)</li>
- +<li>air outlining the falciform ligament (<a href="/articles/football-sign-2">football sign</a>)</li>
- +<li>it is important to note that only 50-75% of patients with proven perforation will have visible free gas <sup>5</sup>
- +</li>
- +</ul>
- +</li>
- +</ul><h5>Ultrasound</h5><ul>
- +<li>bowel wall thickening </li>
- +<li>alteration of vascular state<ul>
- +<li>hypervascular (viable but engorged in early stage)</li>
- +<li>hypovascular (infarcted in later stage)</li>
- +</ul>
- +</li>
- +<li>intramural gas manifesting as hyperechoic foci within the bowel wall</li>
- +<li>free fluid especially with echogenic debris is suspicious for perforation <sup>5</sup>
- +</li>
- +</ul><h4>Treatment and prognosis</h4><p>NEC can be managed both medically and surgically and appropriate patient selection is essential in optimising outcome. A clinical staging system has been developed (see <a href="/articles/necrotising-enterocolitis-staging">necrotising enterocolitis staging</a>), with stage I and II receiving medical therapy and stage III undergoing surgery <sup>8</sup>.</p><p>Medical management consists of supportive measures and cessation of oral feeding, along with broad spectrum antibiotics and gastric aspiration <sup>7</sup>. </p><p>Surgery is usually reserved for patients with evidence of perforation, and entails resection of clearly necrotic bowel and the creation of a proximal enterostomy <sup>5-6</sup>. Other relative indications for surgery include <a href="/articles/portal-venous-gas">portal venous gas</a>, a fixed dilated loop on serial x-rays and abdominal wall erythema <sup>7</sup>. Re-anastomosis is usually delayed until the infant has completely recovered.</p><p>Despite therapy, mortality remains significant, ranging between 9 and 28% <sup>5</sup>. Furthermore ~20% of surviving patients will go on to develop stricture. These are more commonly in the <a href="/articles/large-intestine-1">large bowel</a> (80%) and may result in bowel obstruction weeks to months later <sup>5, 8</sup>.</p><h4>Differential diagnosis</h4><p>In the correct clinical scenario the presence of gas within bowel wall has little differential.<br>Conditions worth keeping in mind include <sup>8</sup>:</p><ul>
- +<li><a href="/articles/pneumatosis-coli">pneumatosis coli</a></li>
- +<li><a href="/articles/neonatal-appendicitis">neonatal appendicitis</a></li>
- +<li><a href="/articles/meconium-ileus">meconium ileus</a></li>
- +<li><a href="/articles/hirschsprung-disease">Hirschsprung disease</a></li>
- +<li><a href="/articles/infectious-enterocolitis">infectious enterocolitis</a></li>