Neuroendocrine tumors
Updates to Article Attributes
Neuroendocrine tumours (NET's) represent a large spectrum of disease. They consist of a large heterogeneous group of malignancies that are derived from embryonic neural crest tissue found in various organ such as the hypothalamus, pituitary gland, thyroid gland, adrenal medulla, and gastrointestinal tract.
The spectrum of neuroendocrine turmours range from:
- carcinoid tumours: arising from enterochromaffin cells and can occur at various sites such as thymus, lung, ovary
- pheochromocytoma: typically occurs in the adrenals but can also occur in extra adrenal sites
- location dependant entities:
- abdomen:
- thorax/lung: pulmonary neuroendocrine tumours
- endocrine glands
- thyroid: medullary thyroid tumours
Pathology
They can also be divided by their biochemical behaviour as functioning or non-functioning, by their aggressiveness as slow-growing and more aggressive lesions and so on.
Because of secretory products by amine precursor uptake and decarboxylation (APUD) they are also known as APUDomas, which is more historical and should not be used anymore.
Genetics
Mostly occur sporadically, some are linked to multiple endocrine neoplasia syndromes.
-<li>location dependant entities<ul>-<li>abdomen <ul>- +<li>location dependant entities:<ul>
- +<li>abdomen:<ul>
-</ul><h4>Pathology</h4><p>They can also be divided by their biochemical behaviour as <strong>functioning</strong> or <strong>non-functioning</strong>, by their aggressiveness as slow-growing and more aggressive lesions and so on.</p><p>Because of secretory products by <em>amine precursor uptake and decarboxylation</em> (APUD) they are also known as APUDomas, which is more historical and should not be used anymore.</p><h5>Genetics</h5><p>Mostly occur sporadically, some are linked to <a href="/articles/multiple-endocrine-neoplasia-syndromes">multiple endocrine neoplasia syndromes</a>.</p>- +</ul><h4>Pathology</h4><p>They can also be divided by their biochemical behaviour as functioning or non-functioning, by their aggressiveness as slow-growing and more aggressive lesions and so on.</p><p>Because of secretory products by amine precursor uptake and decarboxylation (APUD) they are also known as APUDomas, which is more historical and should not be used anymore.</p><h5>Genetics</h5><p>Mostly occur sporadically, some are linked to <a href="/articles/multiple-endocrine-neoplasia-syndromes">multiple endocrine neoplasia syndromes</a>.</p>
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