Non-steroidal anti-inflammatory drug exacerbated respiratory disease
Updates to Article Attributes
Non-steroidal anti-inflammatory drug (NSAID) exacerbated respiratory disease, also known as Samter syndrome (or triad), Widal syndrome, aspirin-induced asthma, or analgesic-induced asthma, refers
- hypersensitivity to aspirin (and other NSAIDs)
- nasal polyposis/rhinosinusitis
- asthma
Terminology
Non-steroidal anti-inflammatory drug exacerbated respiratory disease is also known as Samter syndrome (or triad), Widal syndrome, aspirin-induced asthma, aspirin exacerbated respiratory disease (AERD) and analgesic-induced asthma.
Epidemiology
In adults, prevalence ranges between 8-20% among those given an oral provocation test (OPT), and around 3-5% among patients who self-report that they have the triad 5.
Treatment and prognosis
Treatment is largely centeredcentred around avoiding aspirin, treating underlying asthma and occasionally sinonasal polypectomy (surgical or medical). Unfortunately recurrences are common 2.
Aspirin desensitization has also been tried with at least some short term improvement 2.
History and etymology
The name Samter triad or syndrome was named after the American allergy physician Max Samter (1908-1998) 7 who was the first to comprehensively describe this clinical triad in 1968 6.
-<p><strong>Non-steroidal anti-inflammatory drug (NSAID) exacerbated respiratory disease</strong>, also known as <strong>Samter </strong><strong>syndrome (or triad)</strong>, <strong>Widal syndrome, aspirin-induced asthma</strong>, or <strong>analgesic-induced asthma</strong>, refers to the clinical constellation of <sup>1,2</sup>:</p><ul>-<li>hypersensitivity to <a title="Aspirin" href="/articles/aspirin">aspirin</a> (and other <a href="/articles/non-steroidal-anti-inflammatory-drugs">NSAIDs</a>)</li>- +<p><strong>Non-steroidal anti-inflammatory drug (NSAID) exacerbated respiratory disease</strong>, refers to the clinical constellation of <sup>1,2</sup>:</p><ul>
- +<li>hypersensitivity to <a href="/articles/aspirin">aspirin</a> (and other <a href="/articles/non-steroidal-anti-inflammatory-drugs">NSAIDs</a>)</li>
-</ul><h4>Epidemiology</h4><p>In adults, prevalence ranges between 8-20% among those given an oral provocation test (OPT), and around 3-5% among patients who self-report that they have the triad<sup> 5</sup>.</p><h4>Treatment and prognosis</h4><p>Treatment is largely centered around avoiding <a title="Aspirin" href="/articles/aspirin">aspirin</a>, treating underlying <a title="Asthma" href="/articles/asthma-1">asthma</a> and occasionally sinonasal polypectomy (surgical or medical). Unfortunately recurrences are common <sup>2</sup>. </p><p>Aspirin desensitization has also been tried with at least some short term improvement <sup>2</sup>. </p><h4>History and etymology</h4><p>The name Samter triad or syndrome was named after the American allergy physician <strong>Max</strong> <strong>Samter</strong> (1908-1998) <sup>7</sup> who was the first to comprehensively describe this clinical triad in 1968 <sup>6</sup>.</p>- +</ul><h4>Terminology</h4><p>Non-steroidal anti-inflammatory drug exacerbated respiratory disease is also known as <strong>Samter </strong><strong>syndrome (or triad)</strong>, <strong>Widal syndrome</strong>,<strong> aspirin-induced asthma</strong>, <strong>aspirin exacerbated respiratory disease</strong> (<strong>AERD</strong>) and <strong>analgesic-induced asthma</strong>.</p><h4>Epidemiology</h4><p>In adults, prevalence ranges between 8-20% among those given an oral provocation test (OPT), and around 3-5% among patients who self-report that they have the triad<sup> 5</sup>.</p><h4>Treatment and prognosis</h4><p>Treatment is largely centred around avoiding <a href="/articles/aspirin">aspirin</a>, treating underlying <a href="/articles/asthma-1">asthma</a> and occasionally sinonasal polypectomy (surgical or medical). Unfortunately recurrences are common <sup>2</sup>. </p><p>Aspirin desensitization has also been tried with at least some short term improvement <sup>2</sup>. </p><h4>History and etymology</h4><p>The name Samter triad or syndrome was named after the American allergy physician <strong>Max</strong> <strong>Samter</strong> (1908-1998) <sup>7</sup> who was the first to comprehensively describe this clinical triad in 1968 <sup>6</sup>.</p>
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