Ovarian epithelial tumors
Updates to Article Attributes
Ovarian epithelial tumours account for the majority of of all ovarian tumours (60-70%) and their malignant forms represent >90% of ovarian cancers 1. They can range from being benign to highly malignant.
Epidemiology
There is a difference in frequency of ovarian tumour subtypes depending on menopausal status 6:
-
premenopausal
- serous (~60%)
- mucinous (~20%)
- endometrioid (~10%)
- clear cell (~5%)
- other (~5%)
-
postmenopausal
- serous (~60%)
- endometrioid (~12.5%)
- clear cell (~10%)
- mucinous (~7.5%)
- other (~10%)
Pathology
The origin and pathogenesis of epithelial ovarian cancer ovarian cancer are poorly understood 5. Despite extensive studies, no precursor precursor lesions have been found5.
Classification
-
ovarian serous tumours
- ovarian serous cystadenoma: ~60% of serous tumours
- ovarian borderline serous cystadenoma: ~15% of serous tumours
- ovarian serous cystadenocarcinoma: ~25% of serous tumours (most common malignant ovarian tumour)
-
ovarian mucinous tumours: ~20% of all ovarian tumours
- ovarian mucinous cystadenoma: ~80% of mucinous tumours
- ovarian borderline mucinous cystadenoma: 10-15% of mucinous tumours
- ovarian mucinous cystadenocarcinoma: ~5-10% of mucinous tumours
- ovarian endometrioid tumour: 8-15% of all ovarian tumours
- ovarian cystadenofibroma* / ovarian adenofibroma: can be serous, mucinous, endometrioid, clear cell, or mixed
- ovarian cystadenocarcinofibroma: extremely rare
-
clear cell
ovarianovarian carcinoma: ~5% of ovarian cancer - Brenner tumour: 2-3% of ovarian epithelial neoplasms
- undifferentiated carcinoma of the ovary: ~4% of all ovarian tumours
- squamous cell carcinoma of the ovary
* sometimes classified as a separate category rather than under epithelial
Markers
Radiographic features
These can range from being cystic, to solid, to anything in between. As a crude rule, the likelihood of malignancy increases with increasing solid-tissue elements and thicker septae 2. While there are some common features, there are also many variations and it may be best to refer to subarticles for specific imaging features.
-<p><strong>Ovarian epithelial tumours </strong>account for the majority of all <a href="/articles/ovarian-tumours">ovarian tumours</a> (60-70%) and their malignant forms represent >90% of ovarian cancers <sup>1</sup>. They can range from being benign to highly malignant.</p><h4>Pathology</h4><p>The origin and pathogenesis of epithelial ovarian cancer are poorly understood <sup>5</sup>. Despite extensive studies, no precursor lesions have been found <sup>5</sup>.</p><h5>Classification</h5><ul>- +<p><strong>Ovarian epithelial tumours </strong>account for the majority of all <a href="/articles/ovarian-tumours">ovarian tumours</a> (60-70%) and their malignant forms represent >90% of ovarian cancers <sup>1</sup>. They can range from being benign to highly malignant.</p><h4>Epidemiology</h4><p>There is a difference in frequency of ovarian tumour subtypes depending on menopausal status <sup>6</sup>:</p><ul>
- +<li>
- +<strong>premenopausal</strong><ul>
- +<li>serous (~60%)</li>
- +<li>mucinous (~20%)</li>
- +<li>endometrioid (~10%)</li>
- +<li>clear cell (~5%)</li>
- +<li>other (~5%)</li>
- +</ul>
- +</li>
- +<li>
- +<strong>postmenopausal</strong><ul>
- +<li>serous (~60%)</li>
- +<li>endometrioid (~12.5%)</li>
- +<li>clear cell (~10%)</li>
- +<li>mucinous (~7.5%)</li>
- +<li>other (~10%)</li>
- +</ul>
- +</li>
- +</ul><h4>Pathology</h4><p>The origin and pathogenesis of epithelial ovarian cancer are poorly understood <sup>5</sup>. Despite extensive studies, no precursor lesions have been found <sup>5</sup>.</p><h5>Classification</h5><ul>
-<a href="/articles/clear-cell-ovarian-carcinoma">clear cell ovarian carcinoma</a>: ~5% of ovarian cancer</li>- +<a href="/articles/clear-cell-ovarian-carcinoma">clear cell ovarian carcinoma</a>: ~5% of ovarian cancer</li>
References changed:
- 6. Moorman P, Calingaert B, Palmieri R et al. Hormonal Risk Factors for Ovarian Cancer in Premenopausal and Postmenopausal Women. Am J Epidemiol. 2008;167(9):1059-69. <a href="https://doi.org/10.1093/aje/kwn006">doi:10.1093/aje/kwn006</a> - <a href="https://www.ncbi.nlm.nih.gov/pubmed/18303003">Pubmed</a>
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