Ovarian mucinous tumors

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Ovarian mucinous tumours are a subgroup of ovarian epithelial tumours. They represent ~~~10~~10-15% of all ovarian tumours and ~10% of all malignant ovarian tumours. They are subdivided according to their malignant potential and clinical behaviour into:

Clinical presentation

More common in women ~~ages~~aged 20-50 years old ⁶.

Pathology

On histology they show multiple cysts lined by mucinous epithelium, often resembling gastrointestinal-type epithelium ⁶. KRAS mutations are a common feature.

Subtypes

Mucinous ovarian tumours can be broadly ~~sub-classified~~subclassified into three main subgroups:

ovarian mucinous cystadenoma: ~80 %
ovarian borderline mucinous tumour: ~10-15 %
ovarian mucinous cystadenocarcinoma: ~5-10 %

Radiographic features

In general, the cell type (e.g. serous, mucinous) often cannot be determined by the appearance on imaging ⁵. While some of the specific features can vary between the subtypes, there are certain features which are more common among mucinous tumours: ³

often larger than their serous counterparts (on occasion they may be enormous)
tend to be more multilocular with small cystic components +/- honeycomb-like locules
calcification is comparatively rare and if present tends to be linear
usually unilateral
peritoneal carcinomatosis is less common compared with serous tumours
may have accompanying pseudomyxoma peritonei

MRI

T1
- signal intensity of locules varies depending on the degree of mucin concentration
- loculi with watery mucin have a lower signal intensity than loculi with thicker mucin
T2
- the above-mentioned corresponding signal intensities are flipped so that loculi with watery mucin have a higher signal intensity and loculi with thicker mucin appear slightly hypointense
- the combination of locules with different signal intensities may result in a "stained glass appearance"

Treatment and prognosis

Prognosis of mucinous tumours is highly dependent on the stage and histologic composition: see individual subtypes for further details. Primary treatment is surgical unless there is extra-ovarian disease ⁶.

Differential diagnosis

ovarian serous tumours
- tend to be unilocular
- often smaller than mucinous tumours
- more frequently bilateral
- calcifications (psammoma calcifications)
haemorrhagic cyst
- smaller
- unilocular
- resolves on a follow-up scan
endometrioma
- high signal on T1 weighted images with T2 shading (signal characteristics typical of blood products)

-<p><strong>Ovarian mucinous tumours</strong> are a subgroup of <a href="/articles/epithelial-ovarian-tumours">ovarian epithelial tumours</a>. They represent ~10-15% of all ovarian tumours and ~10% of all malignant ovarian tumours. They are subdivided according to their malignant potential and clinical behaviour into:</p><ul>
+<p><strong>Ovarian mucinous tumours</strong> are a subgroup of <a href="/articles/epithelial-ovarian-tumours">ovarian epithelial tumours</a>. They represent 10-15% of all ovarian tumours and ~10% of all malignant ovarian tumours. They are subdivided according to their malignant potential and clinical behaviour into:</p><ul>
-</ul><h4>Clinical presentation</h4><p>More common in women ages 20-50 years old <sup>6</sup>.</p><h4>Pathology</h4><p>On histology they show multiple cysts lined by mucinous epithelium, often resembling gastrointestinal-type epithelium <sup>6</sup>. KRAS mutations are a common feature.</p><h5>Subtypes</h5><p>Mucinous ovarian tumours can be broadly sub-classified into three main subgroups:</p><ul>
+</ul><h4>Clinical presentation</h4><p>More common in women aged 20-50 years old <sup>6</sup>.</p><h4>Pathology</h4><p>On histology they show multiple cysts lined by mucinous epithelium, often resembling gastrointestinal-type epithelium <sup>6</sup>. KRAS mutations are a common feature.</p><h5>Subtypes</h5><p>Mucinous ovarian tumours can be broadly subclassified into three main subgroups:</p><ul>
-</ul><h4>Treatment and prognosis</h4><p>Prognosis of mucinous tumours is highly dependent on stage and histologic composition: see individual subtypes for further details. Primary treatment is surgical unless there is extra-ovarian disease <sup>6</sup>.</p><h4>Differential diagnosis</h4><ul>
+</ul><h4>Treatment and prognosis</h4><p>Prognosis of mucinous tumours is highly dependent on the stage and histologic composition: see individual subtypes for further details. Primary treatment is surgical unless there is extra-ovarian disease <sup>6</sup>.</p><h4>Differential diagnosis</h4><ul>

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