Postaxial polydactyly
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Postaxial polydactyly refers to polydactyly where the additional digit is on the ulnar margin of the hand, or lateral to the 5th (little) toe.
Epidemiology
Postaxial polydactyly is more common than preaxial polydactyly, with an estimated incidence of 1 in 3000 5.
Associations
Postaxial polydactyly can be associated with:
- trisomy 13
- Bardet-Biedl syndrome
- Meckel Gruber syndrome
- McKusick-Kaufman syndrome
- following oral-facial-digital syndromes (OFDS)
- certain skeletal dysplasias
- Smith Lemli Opitz syndrome
- certain short rib polydactyly syndromes: e.g types I and III
Pathology
The majority of cases are idiopathic. Associations with mutations to the GLI3 gene on chromosome 7 as well as a second locus mapped to chromosome 13 have been implicated in postaxial polydactyly 5.
Classification
Postaxial polydactyly has been defined by Temtamy and McKusick as:
- type A: additional digit at the MCP joint (or more proximally at the CMC joint)
- type B: small nubbin of non-functioning tissue or additional soft tissue on a pedicle
Or, you can use a separate three-part classification system:
- type I: nubbin or floating digit
- type II: duplications at the MCPJ
- type III: duplication of the entire ray
-</ul><h4>Pathology</h4><p>The majority of cases are idiopathic. Associations with mutations to the <em>GLI3 </em>gene on chromosome 7 as well as a second locus mapped to chromosome 13 have been implicated in postaxial polydactyly <sup>5</sup>.</p><h5>Classification</h5><p><a href="/articles/pre-axial-and-post-axial-borders">Postaxial</a> polydactyly has been defined by Temtamy and McKusick as:</p><ul>- +</ul><h4>Pathology</h4><p>The majority of cases are idiopathic. Associations with mutations to the <em>GLI3 </em>gene on chromosome 7 as well as a second locus mapped to chromosome 13 have been implicated in postaxial polydactyly <sup>5</sup>.</p><h5>Classification</h5><p><a href="/articles/preaxial-and-postaxial-borders">Postaxial</a> polydactyly has been defined by Temtamy and McKusick as:</p><ul>
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