ROS1 mutation
Updates to Article Attributes
Title
was changed:
Body
was changed:
The ROS 1ROS1 mutation is a mutation occurring in the ROS 1ROS1 oncogene inon chromosome 6 resulting in a defective receptor tyrosine kinase which has structural similarity to the anaplastic lymphoma kinase (ALK) protein.
It is thought to be present in several cancers of the subtype non-small cell lung cancers (NSCLC) (1-2%).
Clinical importance
Useful for assessing appropriateness of treatment agents such as crizotinib.
History and etymology
It is thought to have been first identified by Rikova et al 3.
See also
-<p>The <strong>ROS 1 mutation</strong> is a mutation occurring in the <em>ROS 1</em> oncogene in chromosome 6 resulting in a defective receptor tyrosine kinase which has structural similarity to the anaplastic lymphoma kinase (ALK) protein.</p><p>It is thought to be present in several cancers of the subtype <a title="Non small cell lung cancer" href="/articles/non-small-cell-lung-cancer-2">non-small cell lung cancers (NSCLC)</a> (1-2%).</p><h4>Clinical importance</h4><p>Useful for assessing appropriateness of treatment agents such as crizotinib.</p><h4>History and etymology</h4><p>It is thought to have been first identified by <strong>Rikova</strong> et al <sup>3</sup>.</p><h4>See also</h4><ul>- +<p>The <strong>ROS1 mutation</strong> is a mutation occurring in the <em>ROS1</em> oncogene on chromosome 6 resulting in a defective receptor tyrosine kinase which has structural similarity to the anaplastic lymphoma kinase (ALK) protein.</p><p>It is thought to be present in several cancers of the subtype <a href="/articles/non-small-cell-lung-cancer-2">non-small cell lung cancers (NSCLC)</a> (1-2%).</p><h4>Clinical importance</h4><p>Useful for assessing appropriateness of treatment agents such as crizotinib.</p><h4>History and etymology</h4><p>It is thought to have been first identified by <strong>Rikova</strong> et al <sup>3</sup>.</p><h4>See also</h4><ul>
Updates to Link Attributes
Title
was removed:
Type
was removed.
Visible
was set to
.
Unable to process the form. Check for errors and try again.