Sarcoidosis (musculoskeletal manifestations)
Updates to Article Attributes
Body
was changed:
Musculoskeletal manifestations of sarcoidosis occur in ~20% (range 4 4-38%) of patients with sarcoidosis and include joint involvement, bone lesions, and muscular disease. Approximately 25% of patients with sarcoidosis have associated arthropathy.
Pathology
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joints: joint involvement in sarcoidosis
- radiographically identifiable pathology is rare
- can be acute occurring isolated or as part of theLöfgren syndrome
- less commonly chronic arthritis presenting as non-deforming granulomatous synovitis or deforming non-erosive arthritis
(Jacoud(Jacoud's deformity) - dactylitis and/or tenosynovitis
- commonest joints to be involved the ankles, knees, elbows, and wrists
-
muscles: muscle involvement in sarcoidosis
- muscles involvement occurs around 50-80%, but symptomatic in only 0.5-2.5%, mostly when the diaphragm or extra-ocular muscles are involved
- can be chronic proximal myopathy or less commonly acute mimicking polymyositis
- nodular pattern myopathy manifest as single or multiple painful nodules
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bones: skeletal sarcoidosis
- hands are mainly affected
- lace-like patternof bone destruction in the metaphysis,
- cystic
bonebone lesions with well defined margins andlyticlytic bone lesions with periosteal reaction - remodelling of the cortex of phalanges, in which the concave shaft is converted into a tubular structure
- sclerotic bone lesions
- osteopaenia/osteoporosis
-<p><strong>Musculoskeletal manifestations of sarcoidosis</strong> occur in ~20% (range 4-38%) of patients with <a href="/articles/sarcoidosis-1">sarcoidosis</a> and include joint involvement, bone lesions, and muscular disease. Approximately 25% of patients with sarcoidosis have associated arthropathy. </p><h4>Pathology</h4><ul>- +<p><strong>Musculoskeletal manifestations of sarcoidosis</strong> occur in ~20% (range 4-38%) of patients with <a href="/articles/sarcoidosis-1">sarcoidosis</a> and include joint involvement, bone lesions, and muscular disease. Approximately 25% of patients with sarcoidosis have associated arthropathy. </p><h4>Pathology</h4><ul>
-<li>can be acute occurring isolated or as part of the <a href="/articles/l-fgren-syndrome">Löfgren syndrome</a>- +<li>can be acute occurring isolated or as part of the <a href="/articles/l-fgren-syndrome">Löfgren syndrome</a>
-<li>less commonly chronic arthritis presenting as non-deforming granulomatous synovitis or deforming non-erosive arthritis (Jacoud's deformity)</li>- +<li>less commonly chronic arthritis presenting as non-deforming granulomatous synovitis or deforming non-erosive arthritis (<a title="Jaccoud arthropathy" href="/articles/jaccoud-arthropathy">Jacoud's deformity</a>)</li>
-<li>cystic bone lesions with well defined margins and lytic bone lesions with periosteal reaction </li>- +<li>cystic bone lesions with well defined margins and lytic bone lesions with periosteal reaction </li>
-<a title="Generalised osteopaenia" href="/articles/generalised-osteopaenia">osteopaenia</a>/<a href="/articles/osteoporosis-3">osteoporosis</a>- +<a href="/articles/generalised-osteopaenia">osteopaenia</a>/<a href="/articles/osteoporosis-3">osteoporosis</a>
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