Schiller-Duval body (histology)
Updates to Article Attributes
Schiller-Duval body is a perivascular structure that that can be found in 50% of testicular yolk sac sac tumours also known asendodermal sinus tumours. If present it is considered pathognomonic.
Pathology
A central vessel is surrounded by tumour cells, and the cell-vessel complex is contained in a cystic space, often lined by flattened tumour cells. It represents represents an attempt to form yolk sacs. The cell-vessel complex is said to resemble a glomerulus.
Immunofluorescent staining may reveal eosinophilic hyalin-like globules both inside and outside the cytoplasm. The globules contain contain AFP and alpha 1-antitrypsin.
History and etymology
It is named after Mathias-Marie Duval (1844-1907), French professor of anatomy and histology, andWalter Schiller (1887-1960), Austrian-born American pathologist.
-<p><strong>Schiller-Duval body</strong> is a perivascular structure that can be found in 50% of <a href="/articles/testicular-yolk-sac-tumour">testicular yolk sac tumours</a> also known as <a href="/articles/ovarian-yolk-sac-tumour">endodermal sinus tumours</a>. If present it is considered pathognomonic. </p><h4>Pathology</h4><p>A central vessel is surrounded by tumour cells, and the cell-vessel complex is contained in a cystic space, often lined by flattened tumour cells. It represents an attempt to form yolk sacs. The cell-vessel complex is said to resemble a glomerulus.</p><p>Immunofluorescent staining may reveal eosinophilic hyalin-like globules both inside and outside the cytoplasm. The globules contain contain AFP and alpha 1-antitrypsin.</p><h4>History and etymology</h4><p>It is named after <strong>Mathias-Marie Duval </strong>(1844-1907), French professor of anatomy and histology, and <strong>Walter Schiller</strong> (1887-1960), Austrian-born American pathologist.</p>- +<p><strong>Schiller-Duval body</strong> is a perivascular structure that can be found in 50% of <a href="/articles/testicular-yolk-sac-tumour">testicular yolk sac tumours</a> also known as <a href="/articles/ovarian-yolk-sac-tumour">endodermal sinus tumours</a>. If present it is considered pathognomonic. </p><h4>Pathology</h4><p>A central vessel is surrounded by tumour cells, and the cell-vessel complex is contained in a cystic space, often lined by flattened tumour cells. It represents an attempt to form yolk sacs. The cell-vessel complex is said to resemble a glomerulus.</p><p>Immunofluorescent staining may reveal eosinophilic hyalin-like globules both inside and outside the cytoplasm. The globules contain contain AFP and alpha 1-antitrypsin.</p><h4>History and etymology</h4><p>It is named after <strong>Mathias-Marie Duval </strong>(1844-1907), French professor of anatomy and histology, and <strong>Walter Schiller</strong> (1887-1960), Austrian-born American pathologist.</p>
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