Spindle cell hepatocellular carcinoma
Updates to Synonym Attributes
Updates to Synonym Attributes
Updates to Synonym Attributes
Updates to Article Attributes
Spindle cell hepatocellular carcinoma (also called sarcomatoid hepatocellular carcinoma), is a rare variant of hepatocellular carcinoma (HCC).
These patients are reported to have low or normal AFP levels, otherwise risk factors and clinical presentation are similar to typical hepatocellular carcinoma.
Epidemiology
The spindle cell variant occurred in approximately~ 2% of surgically resected hepatocellular carcinoma specimens in one study.1,2.
Pathology
Spindle cell HCC is thought to arise either sporadically, or more commonly degenerate from an existing HCC secondary to therapies such as transcatheter arterial chemoembolisation (TACE), radiofrequency (RF) ablation, or percutaneous ethanol injection 2.
Histology
A variable percentage of the tumour contains spindle-shaped cells forming interlacing bundles. This is thought to represent sarcomatous differentiation of hepatocellular carcinoma.
Radiographic features
Currently, there are no specific imaging features and cases are diagnosed retrospectively.
Treatment and prognosis
There is no standard treatment. The difference between typical hepatocellular carcinoma and the spindle cell variant is uncertain, but prognosis is thought to be poor, partly because metastasis is thought to be more common in the spindle cell variant.1.
-<p><strong>Spindle cell hepatocellular carcinoma </strong>(also called <strong>sarcomatoid hepatocellular carcinoma</strong>), is a rare variant of <a title="Hepatocellular carcinoma" href="/articles/hepatocellular-carcinoma">hepatocellular carcinoma</a>.</p><p>These patients are reported to have low or normal AFP levels, otherwise risk factors and clinical presentation are similar to typical hepatocellular carcinoma.</p><h4>Epidemiology</h4><p>The spindle cell variant occurred in approximately 2% of surgically resected hepatocellular carcinoma specimens in one study.<sup>1</sup></p><h4>Pathology</h4><p>A variable percentage of the tumour contains spindle-shaped cells forming interlacing bundles. This is thought to represent sarcomatous differentiation of hepatocellular carcinoma.</p><h4>Radiographic features</h4><p>Currently, there are no specific imaging features and cases are diagnosed retrospectively.</p><h4>Treatment and prognosis</h4><p>There is no standard treatment. The difference between typical hepatocellular carcinoma and the spindle cell variant is uncertain, but prognosis is thought to be poor, partly because metastasis is thought to be more common in the spindle cell variant.<sup>1</sup></p>- +<p><strong>Spindle cell hepatocellular carcinoma </strong>(also called <strong>sarcomatoid hepatocellular carcinoma</strong>), is a rare variant of <a href="/articles/hepatocellular-carcinoma">hepatocellular carcinoma</a> (HCC).</p><p>These patients are reported to have low or normal AFP levels, otherwise risk factors and clinical presentation are similar to typical hepatocellular carcinoma.</p><h4>Epidemiology</h4><p>The spindle cell variant occurred in ~ 2% of surgically resected hepatocellular carcinoma specimens <sup>1,2</sup>.</p><h4>Pathology</h4><p>Spindle cell HCC is thought to arise either sporadically, or more commonly degenerate from an existing HCC secondary to therapies such as transcatheter arterial chemoembolisation (TACE), radiofrequency (RF) ablation, or percutaneous ethanol injection <sup>2</sup>. </p><h5>Histology</h5><p>A variable percentage of the tumour contains spindle-shaped cells forming interlacing bundles. This is thought to represent sarcomatous differentiation of hepatocellular carcinoma.</p><h4>Radiographic features</h4><p>Currently, there are no specific imaging features and cases are diagnosed retrospectively.</p><h4>Treatment and prognosis</h4><p>There is no standard treatment. The difference between typical hepatocellular carcinoma and the spindle cell variant is uncertain, but prognosis is thought to be poor, partly because metastasis is thought to be more common in the spindle cell variant <sup>1</sup>.</p>
References changed:
- 2. Yoshida N, Midorikawa Y, Kajiwara T et-al. Hepatocellular Carcinoma with Sarcomatoid Change without Anticancer Therapies. Case Rep Gastroenterol. 2013;7 (1): 169-74. <a href="http://dx.doi.org/10.1159/000350558">doi:10.1159/000350558</a> - <a href="http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3635691">Free text at pubmed</a> - <a href="http://www.ncbi.nlm.nih.gov/pubmed/23626518">Pubmed citation</a><span class="auto"></span>
- 3. Liver-directed therapy for primary and metastatic liver tumors. Springer. ISBN:0792375238. <a href="http://books.google.com/books?vid=ISBN0792375238">Read it at Google Books</a> - <a href="http://www.amazon.com/gp/product/0792375238">Find it at Amazon</a><span class="auto"></span>
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