T2/FLAIR mismatch sign
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The T2-FLAIR mismatch sign describes the MRI appearance considered highly specific for diffuse or anaplastic astrocytoma (IDH-mutant, 1p/19q-non-codeleted molecular status) as opposed to other lower grade gliomas. On T2WI, the tumor has homogeneously high signal intensity. On T2-FLAIR, the majority of the tumor has relatively hypointense signal, with the exception of a rim of hyperintensity.
-<p>The <strong>T2-FLAIR mismatch sign</strong> describes the MRI appearance considered highly specific for <a title="Diffuse astrocytoma" href="/articles/diffuse-astrocytoma-1">diffuse</a> or <a title="Anaplastic astrocytoma" href="/articles/anaplastic-astrocytoma">anaplastic</a> <a title="Astrocytoma" href="/articles/astrocytic-tumours">astrocytoma</a> (IDH-mutant, 1p/19q-non-codeleted molecular status) as opposed to other lower <a href="/articles/who-grading-system-for-diffuse-astrocytomas">grade</a> gliomas. On T2WI, the tumor has homogeneously high signal intensity. On T2-FLAIR, the majority of the tumor has relatively hypointense signal, with the exception of a rim of hyperintensity.</p>- +<p>The <strong>T2-FLAIR mismatch sign</strong> describes the MRI appearance considered highly specific for <a href="/articles/diffuse-astrocytoma-1">diffuse</a> or <a href="/articles/anaplastic-astrocytoma">anaplastic</a> <a href="/articles/astrocytic-tumours">astrocytoma</a> (IDH-mutant, 1p/19q-non-codeleted molecular status) as opposed to other lower <a href="/articles/who-grading-system-for-diffuse-astrocytomas">grade</a> gliomas. On T2WI, the tumor has homogeneously high signal intensity. On T2-FLAIR, the majority of the tumor has relatively hypointense signal, with the exception of a rim of hyperintensity.</p>
References changed:
- 1. Patel S, Poisson L, Brat D et al. T2–FLAIR Mismatch, an Imaging Biomarker for IDH and 1p/19q Status in Lower-Grade Gliomas: A TCGA/TCIA Project. Clin Cancer Res. 2017;23(20):6078-85. <a href="https://doi.org/10.1158/1078-0432.ccr-17-0560">doi:10.1158/1078-0432.ccr-17-0560</a> - <a href="https://www.ncbi.nlm.nih.gov/pubmed/28751449">Pubmed</a>
- 2. Broen M, Smits M, Wijnenga M et al. The T2-FLAIR Mismatch Sign as an Imaging Marker for Non-Enhancing IDH-Mutant, 1p/19q-Intact Lower-Grade Glioma: A Validation Study. Neuro-Oncology. 2018;20(10):1393-9. <a href="https://doi.org/10.1093/neuonc/noy048">doi:10.1093/neuonc/noy048</a> - <a href="https://www.ncbi.nlm.nih.gov/pubmed/29590424">Pubmed</a>
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- Signs
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- Central Nervous System
Images Changes:
Image 1 MRI (T2) ( create )
Image 2 MRI (FLAIR) ( create )
Image 3 MRI (T2) ( create )
Image 4 MRI (FLAIR) ( create )
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Image 5 MRI (T2) ( create )
Image 6 MRI (FLAIR) ( create )
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