T2/FLAIR mismatch sign

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The T2-FLAIR mismatch sign describes the MRI appearance considered highly specific for diffuse or anaplastic astrocytoma (IDH-mutant, 1p/19q-non-codeleted molecular status) as opposed to other lower grade gliomas. On T2WI, the tumor has homogeneously high signal intensity. On T2-FLAIR, the majority of the tumor has relatively hypointense signal, with the exception of a rim of hyperintensity. This appearance is typical of the entity previously known as protoplasmic astrocytoma.

It is important to note that similar signal characteristics can be seen in the bright rim sign of DNET³.

-The T2-FLAIR mismatch sign describes the MRI appearance considered highly specific for <a href="/articles/diffuse-astrocytoma-1">diffuse</a> or <a href="/articles/anaplastic-astrocytoma">anaplastic</a> <a href="/articles/astrocytic-tumours">astrocytoma</a> (IDH-mutant, 1p/19q-non-codeleted molecular status) as opposed to other lower <a href="/articles/who-grading-system-for-diffuse-astrocytomas">grade</a> gliomas. On T2WI, the tumor has homogeneously high signal intensity. On T2-FLAIR, the majority of the tumor has relatively hypointense signal, with the exception of a rim of hyperintensity. This appearance is typical of the entity previously known as <a href="/articles/protoplasmic-astrocytoma">protoplasmic</a><a href="/articles/protoplasmic-astrocytoma"> astrocytoma</a>.It is important to note that similar signal characteristics can be seen in the <a title="Bright rim sign (DNET)" href="/articles/bright-rim-sign-dnet-1">bright rim sign</a> of <a title="DNET" href="/articles/dysembryoplastic-neuroepithelial-tumour">DNET</a>.
+The T2-FLAIR mismatch sign describes the MRI appearance considered highly specific for <a href="/articles/diffuse-astrocytoma-1">diffuse</a> or <a href="/articles/anaplastic-astrocytoma">anaplastic</a> <a href="/articles/astrocytic-tumours">astrocytoma</a> (IDH-mutant, 1p/19q-non-codeleted molecular status) as opposed to other lower <a href="/articles/who-grading-system-for-diffuse-astrocytomas">grade</a> gliomas. On T2WI, the tumor has homogeneously high signal intensity. On T2-FLAIR, the majority of the tumor has relatively hypointense signal, with the exception of a rim of hyperintensity. This appearance is typical of the entity previously known as <a href="/articles/protoplasmic-astrocytoma">protoplasmic</a><a href="/articles/protoplasmic-astrocytoma"> astrocytoma</a>.It is important to note that similar signal characteristics can be seen in the <a href="/articles/bright-rim-sign-dnet-1">bright rim sign</a> of <a href="/articles/dysembryoplastic-neuroepithelial-tumour">DNET</a> 3.

References changed:

3. Parmar H, Hawkins C, Ozelame R, Chuang S, Rutka J, Blaser S. Fluid-Attenuated Inversion Recovery Ring Sign as a Marker of Dysembryoplastic Neuroepithelial Tumors. Journal of Computer Assisted Tomography. 2007;31(3):348-53. <a href="https://doi.org/10.1097/01.rct.0000243453.33610.9d">doi:10.1097/01.rct.0000243453.33610.9d</a> - <a href="https://www.ncbi.nlm.nih.gov/pubmed/17538277">Pubmed</a>

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T2/FLAIR mismatch sign

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