Talcosis
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Talcosis is a type of pneumoconiosis and can be prevalent in intravenous drug users. It is one of the four recognised types talc induced lung disease.
Pathology
Talc (magnesium silicate) is used in the preparation of tablets intended for oral use, where it acts as a 'filler' and lubricant. When these tablets are ground down, dissolved and injected the talc accumulates in the pulmonary circulation. These deposits result in small foreign body reaction granulomas, which are birefringent under polarized light. If use is persistent the nodules can coalesce to form larger masses.
Radiographic features
Intrinsically hyperdense micronodules (<1mm) can be visible on CT.
HRCTCT
- ground glass opacites 4
- hyperdense micronodules (<1 mm )
- conglomerate masses, similar to progressive massive fibrosis of silicosis 2
- panlobular emphysema though to be as result of methylphenidate (Ritalin) rather than talc
See also
-<p><strong>Talcosis</strong> is a type of <a href="/articles/pneumoconiosis" title="pneumoconiosis">pneumoconiosis</a> and can be prevalent in intravenous drug users. It is one of the four recognised types <a href="/articles/talc-induced-lung-disease" title="talc induced lung disease">talc induced lung disease</a>.</p><h4>Pathology</h4><p>Talc (magnesium silicate) is used in the preparation of tablets intended for oral use, where it acts as a 'filler' and lubricant. When these tablets are ground down, dissolved and injected the talc accumulates in the pulmonary circulation. These deposits result in small foreign body reaction granulomas, which are birefringent under polarized light. If use is persistent the nodules can coalesce to form larger masses.</p><h4>Radiographic features</h4><p>Intrinsically hyperdense micronodules (<1mm) can be visible on CT.</p><h5>HRCT</h5><ul>-<li>-<a href="/articles/ground-glass_opacity">ground glass opacites</a> <sup>4</sup>-</li>-<li>hyperdense micronodules (<1 mm )</li>- +<p><strong>Talcosis</strong> is a type of <a href="/articles/pneumoconiosis">pneumoconiosis</a> and can be prevalent in intravenous drug users. It is one of the four recognised types <a href="/articles/talc-induced-lung-disease">talc induced lung disease</a>.</p><h4>Pathology</h4><p>Talc (magnesium silicate) is used in the preparation of tablets intended for oral use, where it acts as a 'filler' and lubricant. When these tablets are ground down, dissolved and injected the talc accumulates in the pulmonary circulation. These deposits result in small foreign body reaction granulomas, which are birefringent under polarized light. If use is persistent the nodules can coalesce to form larger masses.</p><h4>Radiographic features</h4><p>Intrinsically hyperdense micronodules (<1mm) can be visible on CT.</p><h5>CT</h5><ul>
- +<li>
- +<a href="/articles/ground-glass-opacification">ground glass opacites</a> <sup>4</sup>
- +</li>
- +<li>hyperdense micronodules (<1 mm )</li>
-</li>-<li>-<a href="/articles/panlobular-emphysema">panlobular emphysema</a> though to be as result of methylphenidate (Ritalin) rather than talc</li>- +</li>
- +<li>
- +<a href="/articles/panlobular-emphysema">panlobular emphysema</a> though to be as result of methylphenidate (Ritalin) rather than talc</li>
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