Talcosis
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Talcosis is a type of pneumoconiosis and can be prevalent in intravenous drug users. It is one of the four recognised types of talc-induced lung disease.
Pathology
Talc (magnesium silicate) is used in the preparation of tablets intended for oral use, where it acts as a 'filler' and lubricant. When these tablets are ground down, dissolved and injected for illicit use, the talc accumulates in the pulmonary circulation. These deposits result in small foreign body reaction granulomas, which are birefringent under polarized light. If use is persistent the nodules can coalesce to form larger masses.
Radiographic features
Intrinsically hyperdense micronodules (<1 mm) can be visible on CT.
CT
- ground glass opacities 4
- hyperdense micronodules (<1 mm )
- conglomerate masses, similar to progressive massive fibrosis of silicosis 2
- panlobular emphysema thought to be as a result of methylphenidate (Ritalin) use rather than talc
See also
-<p><strong>Talcosis</strong> is a type of <a href="/articles/pneumoconiosis">pneumoconiosis</a> and can be prevalent in <a title="Intravenous drug users (IVDUs)" href="/articles/intravenous-drug-user">intravenous drug users</a>. It is one of the four recognised types of <a href="/articles/talc-induced-lung-disease-1">talc-induced lung disease</a>.</p><h4>Pathology</h4><p>Talc (magnesium silicate) is used in the preparation of tablets intended for oral use, where it acts as a 'filler' and lubricant. When these tablets are ground down, dissolved and injected for illicit use, the talc accumulates in the pulmonary circulation. These deposits result in small foreign body reaction granulomas, which are birefringent under polarized light. If use is persistent the nodules can coalesce to form larger masses.</p><h4>Radiographic features</h4><p>Intrinsically hyperdense <a href="/articles/fleischner-society-pulmonary-nodule-recommendations-1">micronodules</a> (<1 mm) can be visible on CT.</p><h5>CT</h5><ul>- +<p><strong>Talcosis</strong> is a type of <a href="/articles/pneumoconiosis">pneumoconiosis</a> and can be prevalent in <a href="/articles/intravenous-drug-user">intravenous drug users</a>. It is one of the four recognised types of <a href="/articles/talc-induced-lung-disease-1">talc-induced lung disease</a>.</p><h4>Pathology</h4><p>Talc (magnesium silicate) is used in the preparation of tablets intended for oral use, where it acts as a 'filler' and lubricant. When these tablets are ground down, dissolved and injected for illicit use, the talc accumulates in the pulmonary circulation. These deposits result in small foreign body reaction granulomas, which are birefringent under polarized light. If use is persistent the nodules can coalesce to form larger masses.</p><h4>Radiographic features</h4><p>Intrinsically hyperdense <a href="/articles/fleischner-society-pulmonary-nodule-recommendations-1">micronodules</a> (<1 mm) can be visible on CT.</p><h5>CT</h5><ul>
-<a href="/articles/panlobular-emphysema">panlobular emphysema</a> thought to be as a result of <a title="Methylphenidate lung" href="/articles/ritalin-lung">methylphenidate (Ritalin)</a> use rather than talc</li>- +<a href="/articles/panlobular-emphysema">panlobular emphysema</a> thought to be as a result of <a href="/articles/ritalin-lung">methylphenidate (Ritalin)</a> use rather than talc</li>
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