Toxic leukoencephalopathy (mnemonic)

Changed by Rohit Sharma, 21 Feb 2024
Disclosures - updated 18 Aug 2023: Nothing to disclose

Updates to Article Attributes

Body was changed:

A mnemonic to remember the more common causes of toxic leukoencephalopathy is:

  • CHOICES1

Mnemonic

  • C: chemotherapy (e.g. methotrexate)

  • H: heroin

  • O: other other opioids

  • I: immunosuppressant drugs or imidazole

  • C: cocaine

  • E: ethanol or environmental (e.g.carbon monoxide)

  • S: splenial splenial lesions (reversible secondary to: CLOCCs, antiepileptic drugsantiseizure medications, chemotherapy, immunosuppressant drugs, etc.)

  • -<p>A <strong>mnemonic</strong> to remember the more common causes of <a href="/articles/toxic-leukoencephalopathy">toxic leukoencephalopathy</a> is:</p><ul><li>
  • -<strong>CHOICES</strong>​ <sup>1</sup>
  • -</li></ul><h4>Mnemonic</h4><ul>
  • -<li>
  • -<strong>C: </strong>chemotherapy (e.g. <a href="/articles/methotrexate-related-leukoencephalopathy">methotrexate</a>)</li>
  • -<li>
  • -<strong>H:</strong> <a href="/articles/heroin-induced-leukoencephalopathy">heroin</a>
  • -</li>
  • -<li>
  • -<strong>O:</strong> other opioids</li>
  • -<li>
  • -<strong>I:</strong> <a href="/articles/immunosuppression">immunosuppressant</a> drugs or imidazole</li>
  • -<li>
  • -<strong>C:</strong> cocaine</li>
  • -<li>
  • -<strong>E:</strong> ethanol or environmental (e.g. <a href="/articles/carbon-monoxide-poisoning-1">carbon monoxide</a>)</li>
  • -<li>
  • -<strong>S:</strong> splenial lesions (reversible secondary to: <a href="/articles/cytotoxic-lesions-of-the-corpus-callosum-cloccs">CLOCCs</a>, antiepileptic drugs, chemotherapy, immunosuppressant drugs, etc.)</li>
  • +<p>A <strong>mnemonic</strong> to remember the more common causes of <a href="/articles/toxic-leukoencephalopathy">toxic leukoencephalopathy</a> is:</p><ul><li><p><strong>CHOICES</strong>​&nbsp;<sup>1</sup></p></li></ul><h4>Mnemonic</h4><ul>
  • +<li><p><strong>C: </strong>chemotherapy (e.g. <a href="/articles/methotrexate-related-leukoencephalopathy">methotrexate</a>)</p></li>
  • +<li><p><strong>H:</strong> <a href="/articles/heroin-induced-leukoencephalopathy">heroin</a></p></li>
  • +<li><p><strong>O:</strong>&nbsp;other opioids</p></li>
  • +<li><p><strong>I:</strong> <a href="/articles/immunosuppression">immunosuppressant</a> drugs or imidazole</p></li>
  • +<li><p><strong>C:</strong> cocaine</p></li>
  • +<li><p><strong>E:</strong> ethanol or environmental (e.g.&nbsp;<a href="/articles/carbon-monoxide-poisoning-1">carbon monoxide</a>)</p></li>
  • +<li><p><strong>S:</strong>&nbsp;splenial lesions (reversible secondary to: <a href="/articles/cytotoxic-lesions-of-the-corpus-callosum-cloccs">CLOCCs</a>, antiseizure medications, chemotherapy, immunosuppressant drugs, etc.)</p></li>

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