Troponin

Changed by Daniel J Bell, 1 Dec 2018

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Troponin ~~elevation~~

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Troponin is a protein of key importance in the functioning of skeletal and cardiac muscle. It forms part of the contractile mechanism, and comprises three main subunits: troponin C, troponin I, and troponin T.

Troponin elevation

Elevation of serum troponin can occur from a number of causes ~~although~~. Although there is no imaging involved, it is useful for the radiologist to have a basic understanding of ~~their~~these causes ~~(especially~~, especially when interpreting imaging findings associated with troponin elevation). ~~The cardiac troponin complex consists of three subunits:~~

~~troponin C~~

~~troponin I~~

~~troponin T~~

Aetiology

The list includes:

cardiac causes
- acute myocardial infarction
- following percutaneous coronary intervention
- following open heart surgery
- cardiac failure
  - acute cardiac failure
  - chronic cardiac failure
- acute myocarditis
- acute pericarditis
- cardiotoxic chemotherapy
- following certain cardiac procedures
  - high frequency ablation
  - external current cardioversion
  - defibrillator shocks
- direct cardiac trauma: myocardial contusion
- post cardiac transplantation
- cardiac infiltrative conditions
  - cardiac amyloidosis
non-cardiac causes
- systemic inflammatory response syndrome (SIRS)
- septic shock
- pulmonary embolism: may be elevated in up to half of cases ¹
- strenuous exercise
- renal failure
  - end stage renal failure
- cerebrovascular accidents
  - subarachnoid haemorrhage (SAH) ²
- chronic obstructive pulmonary disease (COPD)

-<p><strong>Troponin elevation</strong> can occur from a number causes although there is no imaging involved, it is useful for the radiologist to have a basic understanding of their causes (especially when interpreting imaging findings associated with troponin elevation). The cardiac troponin complex consists of three subunits:</p><ul>
~~-<li>troponin C</li>~~
~~-<li>troponin I</li>~~
~~-<li>troponin T</li>~~
~~-</ul><h5>Aetiology</h5><p>The list includes:</p><ul>~~
+<p><strong>Troponin</strong> is a protein of key importance in the functioning of skeletal and cardiac muscle. It forms part of the contractile mechanism, and comprises three main subunits: <strong>troponin C</strong>, <strong>troponin I</strong>, and <strong>troponin T</strong>. </p><h4>Troponin elevation</h4><p>Elevation of serum troponin can occur from a number of causes. Although there is no imaging involved, it is useful for the radiologist to have a basic understanding of these causes, especially when interpreting imaging findings associated with troponin elevation. </p><h5>Aetiology</h5><p>The list includes:</p><ul>