Vitamin C
Updates to Article Attributes
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was changed:
Vitamin C (ascorbic acid) is a water soluble vitamin that is a coenzyme for the formation of the structure protein collagen, particularly creating cross-linking of collagen fibres which greatly increases its tensile strength. It also acts as an antioxidant.
History and etymology
Vitamin C was discovered by Albert Szent-Györgyi (1893-1986), a Hungarian biochemist and (non-practising) physician, who emigrated to the USA after World War II. For his vitamin C work he was awarded the Nobel Prize for medicine or physiology in 1937 3.
Related pathology
Pathological manifestations can occur both in excess and deficiency:
- hypervitaminosis C: true toxicity has not been observed,
but the oxidised form ofalthough megadosing (>2 g per day has been associated with nausea, abdominal cramps, diarrhea and kidney stones)-
in vitro experimentation has found that ascorbic acid
can be toxiccauses cell apoptosis at only 100-200 times the recommended daily allowance 2
-
in vitro experimentation has found that ascorbic acid
- hypovitaminosis C: scurvy
-<p><strong>Vitamin C (ascorbic acid)</strong> is a water soluble <a href="/articles/vitamins">vitamin</a> that is a coenzyme for the formation of the structure protein collagen, particularly creating cross-linking of collagen fibres which greatly increases its tensile strength. It also acts as an antioxidant.</p><h4>- +<p><strong>Vitamin C (ascorbic acid)</strong> is a water soluble <a href="/articles/vitamins">vitamin</a> that is a coenzyme for the formation of the structure protein collagen, particularly creating cross-linking of collagen fibres which greatly increases its tensile strength. It also acts as an antioxidant.</p><h4>History and etymology</h4><p>Vitamin C was discovered by <strong>Albert Szent-Györgyi</strong> (1893-1986), a Hungarian biochemist and (non-practising) physician, who emigrated to the USA after World War II. For his vitamin C work he was awarded the <a title="Nobel Prizes for radiology" href="/articles/nobel-prizes-for-radiology">Nobel Prize for medicine or physiology</a> in 1937 <sup>3</sup>.</p><h4>
-<li>hypervitaminosis C has not been observed, but the oxidised form of ascorbic acid can be toxic</li>- +<li>hypervitaminosis C: true toxicity has not been observed, although megadosing (>2 g per day has been associated with nausea, <a href="/articles/acute-abdominal-pain">abdominal cramps</a>, diarrhea and kidney stones)<ul><li>in vitro experimentation has found that ascorbic acid causes cell apoptosis at only 100-200 times the recommended daily allowance <sup>2</sup>
- +</li></ul>
- +</li>
References changed:
- 2. Telang PS. Vitamin C in dermatology. (2013) Indian dermatology online journal. 4 (2): 143-6. <a href="https://doi.org/10.4103/2229-5178.110593">doi:10.4103/2229-5178.110593</a> - <a href="https://www.ncbi.nlm.nih.gov/pubmed/23741676">Pubmed</a> <span class="ref_v4"></span>
- 3. Grzybowski A, Pietrzak K. Albert Szent-Györgyi (1893-1986): the scientist who discovered vitamin C. (2013) Clinics in dermatology. 31 (3): 327-31. <a href="https://www.ncbi.nlm.nih.gov/pubmed/23738385">Pubmed</a> <span class="ref_v4"></span>
- 3. Grzybowski A, Pietrzak K. Albert Szent-Györgyi (1893-1986): the scientist who discovered vitamin C. (2013) Clinics in dermatology. 31 (3): 327-31. <a href="https://www.ncbi.nlm.nih.gov/pubmed/23738385">Pubmed</a> <span class="ref_v4"></span>
- 3.
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