Presentation
Patient with leukemia, taking chemotherapy for 2 years.
Patient Data
In both hemispheres, except for the temporal lobes and more cortico-subcortically on the left, multiple foci of hyperintensity are noted on T2 and T2 FLAIR with a diameter of up to 2.0 cm. In DWI, there is no diffusion restriction in these foci due to T2 shine-through.
Case Discussion
Posterior reversible encephalopathy syndrome (PRES) is a highly uncommon neurological disorder that manifests itself through a variety of neurological symptoms.
There are some reports in which chemotherapy can be linked to PRES, although this is a relatively uncommon occurrence. PRES has been reported to occur in cancer patients who are undergoing chemotherapy, particularly with certain classes of chemotherapeutic agents.The precise mechanisms by which chemotherapy may lead to PRES are not completely understood; however, there are some theories that suggest that it may be related to changes in blood pressure, vascular permeability, or direct toxicity to the brain.
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