Addison disease
Diagnosis almost certain
Updates to Case Attributes
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Granulomatous Infection (Tuberculosis) is the most common infectious cause of Addison disease. CT appearance of granulomatous infection depends on the time and activity of the inflammatory process.
- early stage “adrenalitis” include bilateral adrenal enlargement with a central necrotic area of hypoattenuation and a peripheral enhancing rim.
- In the healing stage of the disease, the adrenal glands become calcified and atrophic (adrenal calcification).
Addison disease may be either acute, subacute,or chronic (62).
- Acute Addison disease occurs within a few weeks to months and is caused by bilateral adrenal hemorrhage (adrenal apoplexy), secondary to shock and sepsis or trauma. On CT scan bilateral adrenal hematomas are demonstrated.
- Subacute disease (adrenalitis): when the disease has been present for less than 2 years. On CT enlargement of both adrenal glands, with necrotic centers and a rim of contrast enhancement are usually demonstrated. CT-guided biopsy helps to identifiy the cause such as tuberculosis, histoplasmosis, and other fungi.
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Chronic disease: may be caused by chronic autoimmune disorder, chronic granulomatous infection (TB or histoplasmosis). On CT both adrenal glands appear small and atrophic with
assciaatedassociated with calcifications in granulomatous adrenalitis.
-<strong>Chronic</strong> disease: may be caused by chronic autoimmune disorder, chronic granulomatous infection (TB or histoplasmosis). On CT both adrenal glands appear small and atrophic with assciaated with calcifications in granulomatous adrenalitis.</li>- +<strong>Chronic</strong> disease: may be caused by chronic autoimmune disorder, chronic granulomatous infection (TB or histoplasmosis). On CT both adrenal glands appear small and atrophic with associated with calcifications in granulomatous adrenalitis.</li>
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