Anaplastic astrocytoma (WHO grade III)

Case contributed by Mohammad A. ElBeialy , 23 Jun 2013
Diagnosis probable
Changed by Ahmed Abdrabou, 20 Nov 2015

Updates to Study Attributes

Findings was changed:
  • right fronto-parietal cortical and subcortical mass lesion is seen demonstrating heterogenous predominantly low T1 with patchy areas of T1 hyperintensity (met Hb sign) as well as heterogeneously hyperintense T2 / FLAIR signal. The lesion shows some restricted diffusion. 
  • the lesion shows mild heterogenous post-contrast enhancement. 
  • the lesion is surrounded by mild vasogenic brain oedema with compression of the right lateral ventricle as well as subtle about 3 mm contra-lateral midline shift. 
  • MR spectroscopy of the examination shows: 
    • marked elevation of the choline (Cho) with moderate depression of the neuronal markers
    • N-acetyl aspartate (NAA) and creatine (Cr) with elevation of the Cho / Cr and Cho / NAA rations
    • Myoinositol (MI) is not significantly depressed, with MI / Cr ratio ~ 0.53
    • single voxel MR spectroscopy show mild elevation of the lipid / lactate peak
  • no hydrocephalic changes
  • normal sellar region
  • normal posterior fossa.

Updates to Case Attributes

Diagnostic Certainty was set to .

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