Cryptococcal leptomeningitis with basal ganglia involvement
Updates to Study Attributes
Lesions in the lentiform and caudate nucleus (basal ganglia), some of them of cystic aspectin nature and predominating to thea left sided predominance.
Leptomeningeal enhancement, in the occipital and temporal lobes, on the right, in the parietal lobes and in the right precentral sulcus, with adjacent vasogenic edema, more evident in the FLAIR sequence, with possible small areas of associated parenchymal enhancement.
Updates to Case Attributes
The patient has a history of HIV/AIDS, with previous cryptococcal meningitis, presenting with a lowering of consciousness level and headache. CSF screening was positive for cryptococcus.
In patients with severe immunodepressionimmunosuppression, the infection of the meninges diffuses to the cerebral parenchyma through the ependymal surface and the subarachnoid spaces, leading. This leads to the accumulation of mucinous exudates, rich in fungus, expressed by dilation of the Virchow-Robin spaces, and they can evolve into mucinous cysts, with a predilection for the basal ganglia and periventricular regions.
In this case there is a lesion in the basal ganglia, which does not show contrast enhancement, however. However, there is leptomeningeal enhancement, which is characteristic of cryptococcal leptomeningitis.
-<p>The patient has a history of HIV/AIDS, with previous cryptococcal meningitis, presenting lowering of consciousness level and headache. CSF screening was positive for cryptococcus.</p><p>In patients with severe immunodepression, the infection of the meninges diffuses to the cerebral parenchyma through the ependymal surface and the subarachnoid spaces, leading to the accumulation of mucinous exudates, rich in fungus, expressed by dilation of the Virchow-Robin spaces, and they can evolve into mucinous cysts, with a predilection for the basal ganglia and periventricular regions.</p><p>In this case there is a lesion in the basal ganglia, which does not show contrast enhancement, however, there is leptomeningeal enhancement, which is characteristic of cryptococcal leptomeningitis.</p>- +<p>The patient has a history of HIV/AIDS, with previous cryptococcal meningitis, presenting with a lowering of consciousness level and headache. CSF screening was positive for cryptococcus.</p><p>In patients with severe immunosuppression, infection of the meninges diffuses to the cerebral parenchyma through the ependymal surface and the subarachnoid spaces. This leads to the accumulation of mucinous exudates, rich in fungus, expressed by dilation of the Virchow-Robin spaces, and they can evolve into mucinous cysts, with a predilection for the basal ganglia and periventricular regions.</p><p>In this case there is a lesion in the basal ganglia, which does not show contrast enhancement. However, there is leptomeningeal enhancement, which is characteristic of cryptococcal leptomeningitis.</p>
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