Marchiafava Bignami syndrome
Updates to Case Attributes
This case illustrates what are probably features of prior Marchiafava Bignami syndrome. Subsequent history obtained offrom the patient, confirmed the presence of a period of severe binge drinking while depressed.
Prior to this, there was no history of alcohol abuse which would have made Marchiafava Bignami syndrome unlikely. Although predominantly of white matter abnormalities, the appearances are not those of a leukodystrophy, CADASIL or CADASIL or MS/ADEM. HIVnegative and non immunosuppressed-immunosuppressed makes PML unlikely (and again I am notsure it involves the cc to this extent). ThereThat there was a vague history of hyponatremiadoes raise the possibility of extrapontinedemyelination, however I am not aware of it involving the body of the CC
corpus callosum (rather the splenium).
Other possibilities include a leukoclastic vasculitis /
or encephalitis illness e.g. SLE, systemic sclerosis, etc..
-<p>This case illustrates what are probably features of prior Marchiafava Bignami syndrome. Subsequent history obtained of the patient, confirmed the presence of a period of severe binge drinking while depressed. </p>-<p>Prior to this, there was no history of alcohol abuse which would have made Marchiafava Bignami syndrome unlikely. Although predominantly of white matter, the appearances are not those of a leukodystrophy or CADASIL or MS / ADEM. HIV-negative and non immunosuppressed makes PML unlikely (and again I am not- sure it involves the cc to this extent). There was a vague history of hyponatremia-does raise the possibility of extrapontine-demyelination, however I am not aware of it involving the body of the CC- (rather the splenium). </p>-<p>Other possibilities include a leukoclastic vasculitis /-encephalitis illness e.g. SLE, systemic sclerosis etc.. </p>- +<p>This case illustrates what are probably features of prior <a title="Marchiafava-Bignami disease" href="/articles/marchiafava-bignami-disease-1">Marchiafava Bignami syndrome</a>. Subsequent history obtained from the patient, confirmed the presence of a period of severe binge drinking while depressed.</p><p>Prior to this, there was no history of alcohol abuse which would have made Marchiafava Bignami syndrome unlikely. Although predominantly white matter abnormalities, the appearances are not those of a leukodystrophy, <a title="Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL)" href="/articles/cerebral-autosomal-dominant-arteriopathy-with-subcortical-infarcts-and-leukoencephalopathy-cadasil-1">CADASIL</a> or <a title="MS" href="/articles/multiple-sclerosis">MS</a>/<a title="Acute disseminated encephalomyelitis (ADEM)" href="/articles/acute-disseminated-encephalomyelitis-adem-1">ADEM</a>. <a title="HIV" href="/articles/hivaids">HIV</a> negative and non-immunosuppressed makes <a title="PML" href="/articles/progressive-multifocal-leukoencephalopathy">PML</a> unlikely (and again I am not sure it involves the cc to this extent). That there was a vague history of hyponatremia does raise the possibility of <a title="Extrapontine myelinolysis" href="/articles/extrapontine-myelinolysis-1">extrapontine demyelination</a>, however I am not aware of it involving the body of the corpus callosum (rather the splenium). </p><p>Other possibilities include a leukoclastic vasculitis or encephalitis illness e.g. <a title="SLE" href="/articles/systemic-lupus-erythematosus">SLE</a>, <a title="Systemic sclerosis" href="/articles/scleroderma">systemic sclerosis</a>, etc.</p>
Updates to Study Attributes
Image MRI (T1 IR) ( update )
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