Methotrexate encephalopathy (probable)

Case contributed by Dr Praveen Jha


Delirium, confusion progressing to coma. Patient got treated for ectopic gestation, with probably high dose methotrexate. Serum B-HCG levels not checked prior to administration, as per records.

Patient Data

Age: 25 years old
Gender: Female

Multiple confluent areas of altered signal intensity are seen in brainstem, thalami, posterior limbs of internal capsule, periventricular and subcortical white matters, with associated edema. Post-contrast enhancement is seen in the periphery of lesions.

Case Discussion

Patient deteriorated rapidly, almost progressing to coma, when she was referred to tertiary neurological set-up, where further investigations were carried out. CSF study did not reveal any inflammatory pathology. Patient succumbed within a week, and methotrexate encephalopathy was considered as most likely diagnosis.. 

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Case information

rID: 26821
Published: 9th Jan 2014
Last edited: 14th Aug 2019
Inclusion in quiz mode: Included

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