Pancreatic neuroendocrine tumor

Case contributed by Melbourne Uni Radiology Masters , 29 Jul 2015
Diagnosis certain
Changed by Bruno Di Muzio, 12 Nov 2016

Updates to Study Attributes

Findings was changed:

CT Abdomen

No evidence of chronic or acute pancreatitis. There is a 3.9 cm x 3.2 cm x 3.2 cm well defined - almost encapsulated appearing - solid enhancing pancreatic head mass demonstrating quite vivid arterial enhancement with persistent hyper enhancement relative to pancreatic parenchyma on portal venous phase. Small non-enhancing cystic spaces are shown, which may represent small areas of necrosis. The mass does not cause main pancreatic duct dilatation or biliary dilatation. The mass is closely associated with the proximal portal vein. The portal vein is slightly displaced and deformed but has a smooth margin where there is contact with the mass. There is a short distance of central superior mesenteric vein in contact with the mass. Contact points at portal vein and superior veins are less than

Coeliac axis, hepatic artery, superior mesenteric artery are clear. No lymphadenopathy.

Within segment 5 of the liver, there is a wedge-shaped area of arterial hyper enhancement, without washout of seen on prior exam. Within segment 8, there is a small focus of arterial hyperenhancement without washout, which may represent a similar phenomenon.

Left renal cyst. While both kidneys, adrenal glands, spleen are normal in appearance. Visible bones are normal in appearance.

Conclusion: Pancreatic head mass, abutting the proximal portal vein without clear evidence of invasion. Differential diagnosis includes neuroendocrine tumour; appearances are not typical for adenocarcinoma. Seg. VIII hypervascular liver lesion is indeterminate. Seg. V hypervascular liver area may represent a THID/THAD.

Suggest consider correlation with EUS/FNA.

Updates to Study Attributes

Findings was changed:

EUS.

Pancreatic head mass lesion, well defined with no vascular invasion noted.

No enlarged lymph nodes are visualised.

Biopsy was performed, there were no complications.

Updates to Quizquestion Attributes

Question was added:
Are pancreatic neuroendocrine tumours more frequently isolated lesions or part of systemic syndromes? Can you name some important syndromes associated with these tumours?
Answer was added:
Most tumours are isolated. 1-2% are associated with the multiple endocrine neoplasia type I (MEN I - characterised by the triad of parathyroid, pituitary, and pancreatic lesions). There are also associations between pancreatic endocrine tumours and von Hippel-Lindau and tuberous sclerosis.

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