Radiation-associated osteosarcoma
Diagnosis probable
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A post-irradiationRadiation-associated osteosarcoma may develop when more than 30Gy is given. There is a latency of more than 3 years after RTradiation therapy, on average 11-14 years. It may mimic osteonecrosis and primary recurrence. Imaging feature of osteosarcoma includes bone-forming tumortumour with soft tissue mass and interval growth. Osteonecrosis on the other hand, usually shows osteopenia and heterogeneous bone density with an absence of a soft tissue mass. It and usually develops 1-3 years after RT andradiation therapy with no significant change over time.
-<p>A post-irradiation osteosarcoma may develop when more than 30Gy is given. There is a latency of more than 3 years after RT, on average 11-14 years. It may mimic osteonecrosis and primary recurrence. Imaging feature of osteosarcoma includes bone-forming tumor with soft tissue mass and interval growth. Osteonecrosis on the other hand, usually shows osteopenia and heterogeneous bone density with absence of soft tissue mass. It usually develops 1-3 years after RT and no significant change over time.</p>- +<p><a title="Radiation-associated osteosarcoma" href="/articles/secondary-osteosarcoma">Radiation-associated osteosarcoma</a> may develop when more than 30Gy is given. There is a latency of more than 3 years after radiation therapy, on average 11-14 years. It may mimic osteonecrosis and primary recurrence. Imaging feature of osteosarcoma includes bone-forming tumour with soft tissue mass and interval growth. Osteonecrosis on the other hand usually shows osteopenia and heterogeneous bone density with an absence of a soft tissue mass and usually develops 1-3 years after radiation therapy with no significant change over time.</p>
References changed:
- 1. Mitchell MJ, Logan PM. Radiation-induced changes in bone. (1998) Radiographics : a review publication of the Radiological Society of North America, Inc. 18 (5): 1125-36; quiz 1242-3. <a href="https://doi.org/10.1148/radiographics.18.5.9747611">doi:10.1148/radiographics.18.5.9747611</a> - <a href="https://www.ncbi.nlm.nih.gov/pubmed/9747611">Pubmed</a> <span class="ref_v4"></span>
- 2. Chabchoub I, Gharbi O, Remadi S, Limem S, Trabelsi A, Hochlef M, Ben Fatma L, Landolsi A, Mokni M, Kraiem C, Ben Ahmed S. Postirradiation osteosarcoma of the maxilla: a case report and current review of literature. (2009) Journal of oncology. 2009: 876138. <a href="https://doi.org/10.1155/2009/876138">doi:10.1155/2009/876138</a> - <a href="https://www.ncbi.nlm.nih.gov/pubmed/19478960">Pubmed</a> <span class="ref_v4"></span>
- 1. Mitchell M, Logan PM, Radiation-induced changes in bone, Radiographics 1998;18:1125-36.
- 2. Chabchoub I et al., Postirradiation osteosarcoma of the maxilla: a case report and current review of literature. Journal of Oncology, 2009.
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