Common variable immunodeficiency (pulmonary manifestations)
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Pulmonary manifestations of common variable immunodeficiency can be variable. The respiratory system is one of the most commenly affected systems in common variable immunodeficiency.
Radiographic disease spectrum
CT chest
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bronchiectasis with interstitial lung disease (e.g. granulomatous-lymphocytic interstitial lung disease)
- could either be due to repeated lung infection or manifestation of dysregulated lymphoid proliferation 1
- bronchiectasis has been reported as up to 65% of patients according to one study 2
- ~10% of patients with common variable immunodeficiency have systemic granulomatous disease with associated interstitial lung disease 5
- pulmonary nodules
- ground glass changes
- lung parenchymal opacification: may be multifocal
- other features
- intrathoracic or intra-abdominal lymphanopathy and/ or hepatosplenomegaly
-<a href="/articles/bronchiectasis">bronchiectasis</a> with <a href="/articles/interstitial-lung-disease">interstitial lung disease</a><ul>- +<a href="/articles/bronchiectasis">bronchiectasis</a> with <a href="/articles/interstitial-lung-disease">interstitial lung disease</a> (e.g. <a title="Granulomatous-lymphocytic interstitial lung disease (GLILD)" href="/articles/granulomatous-lymphocytic-interstitial-lung-disease">granulomatous-lymphocytic interstitial lung disease</a>)<ul>
-<li><a href="/articles/ground-glass-opacification-1">ground glass changes</a></li>- +<li><a href="/articles/ground-glass-opacification-3">ground glass changes</a></li>
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