In utero syphilis infection
Updates to Article Attributes
Body
was changed:
In utero syphilis infection results from transmission from maternal infection from the spiroketespirochete Treponema pallidum.
Pathology
The pathogen is capable of crossing the placenta during any time in gestation.
Markers
The following tests can be assessed on maternal blood
- fluorescent treponemal antibody absorbed test (FTA-ABS)
- rapid plasma reagin (RPR)
- venereal disease research laboratory test (VDRL)
Radiographic features
Antenatal ultrasound
Sonographic features are often non specific and mimic those of the generalised in utero infection.
Such features include
In severe cases there may be evidence of
Treatment and prognosis
Treatment in often with penicillin. Fetal demise or still birth can occur in ~ 50% of intreated cases. Fetal developing hydrops tend to have a very poor prognosis.
-<p><strong>In utero syphilis infection</strong> results from transmission from maternal infection from the spirokete <em><a href="/articles/treponema-pallidum" title="Treponema pallidum">Treponema pallidum</a></em>. </p><h4>Pathology</h4><p>The pathogen is capable of crossing the placenta during any time in gestation. </p><h5>Markers</h5><p>The following tests can be assessed on maternal blood</p><ul style="BORDER-TOP-WIDTH: 0px; PADDING-RIGHT: 0px; PADDING-LEFT: 0px; BORDER-LEFT-WIDTH: 0px; LIST-STYLE-POSITION: outside; FONT-SIZE: 13px; BORDER-BOTTOM-WIDTH: 0px; MARGIN: 0.69em 1em 0.69em 2.75em; VERTICAL-ALIGN: baseline; LINE-HEIGHT: 17px; FONT-FAMILY: inherit; LIST-STYLE-TYPE: disc; BORDER-RIGHT-WIDTH: 0px; outline-width: 0px; outline-style: initial; outline-color: initial">- +<p><strong>In utero syphilis infection</strong> results from transmission from maternal infection from the spirochete <em><a href="/articles/treponema-pallidum">Treponema pallidum</a></em>. </p><h4>Pathology</h4><p>The pathogen is capable of crossing the placenta during any time in gestation. </p><h5>Markers</h5><p>The following tests can be assessed on maternal blood</p><ul>
-</ul><h4>Radiographic features</h4><h5>Antenatal ultrasound</h5><p>Sonographic features are often non specific and mimic those of the generalised <a href="/articles/in-utero-infection" title="In utero infection">in utero infection</a>. </p><p>Such features include</p><ul>-<li><a href="/articles/fetal-hepatosplenomegaly" title="fetal hepatosplenomegaly">fetal hepatosplenomegaly</a></li>-<li><a href="/articles/placentomegaly" title="Placentomegaly">placentomegaly</a></li>-<li><a href="/articles/fetal-ascites" title="Fetal ascites">fetal ascites</a></li>- +</ul><h4>Radiographic features</h4><h5>Antenatal ultrasound</h5><p>Sonographic features are often non specific and mimic those of the generalised <a href="/articles/in-utero-infection">in utero infection</a>. </p><p>Such features include</p><ul>
- +<li><a href="/articles/fetal-hepatosplenomegaly">fetal hepatosplenomegaly</a></li>
- +<li><a href="/articles/placentomegaly">placentomegaly</a></li>
- +<li><a href="/articles/fetal-ascites">fetal ascites</a></li>
-<li><a href="/articles/hydrops-fetalis" title="Fetal hydrops">fetal hydrops</a></li>-<li><a href="/articles/bent-fetal-long-bones" title="bent fetal long bones">bent fetal long bones</a></li>- +<li><a href="/articles/hydrops-fetalis">fetal hydrops</a></li>
- +<li><a href="/articles/bent-fetal-long-bones">bent fetal long bones</a></li>
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