Neuroendocrine tumors

Neuroendocrine tumors (NETs) represent a wide spectrum of disease. They consist of a large heterogeneous group of malignancies that are derived from embryonic neural crest tissue found in various organ such as the hypothalamus, pituitary gland, thyroid gland, adrenal medulla, and gastrointestinal tract. 

The spectrum of neuroendocrine tumors range from:

Pathology

They can also be divided by their biochemical behavior as functioning or non-functioning, by their aggressiveness as slow-growing and more aggressive lesions and so on.

Because of secretory products by amine precursor uptake and decarboxylation (APUD) they were historically known as APUDomas.

Genetics

Mostly occur sporadically, some are linked to multiple endocrine neoplasia syndromes.

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Article information

rID: 28523
System: Oncology
Tag: net
Synonyms or Alternate Spellings:
  • Neuroendocrine tumor
  • Neuroendocrine tumors
  • NET
  • APUD
  • Neuroendocrine tumours (NET's)
  • Neuroendocrine tumour (NET)
  • APUDomas

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