Splenic infarction
Diagnosis almost certain
Updates to Case Attributes
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was changed:
This case demonstrates hepatosplenomegaly with splenic infarction.
Myelofibrosis is a clonal stem cell disorder characterised by splenomegaly, chronic myeloproliferation, bone marrow infiltration, and extramedullary haematopoiesis (EMH) 1. It commonly presents with anaemia, palpable splenomegaly, and constitutional symptoms. Hepatosplenomegaly is a complication of significant extramedullary haematopoiesihaematopoiesis 2. Hepatomegaly and splenomegaly isare seen in up to 40-70% and 90% of patients respectively 3.
Splenic infarction in myelofibrosis results from a combination of infiltration of the splenic parenchyma in EMH, anaemia and increased oxygen requirements of an enlarged spleen.
-<p>This case demonstrates <a title="Hepatosplenomegaly" href="/articles/hepatosplenomegaly">hepatosplenomegaly</a> with <a title="Splenic infarction" href="/articles/splenic-infarction">splenic infarction.</a></p><p><a title="Myelofibrosis" href="/articles/primary-myelofibrosis">Myelofibrosis</a> is a clonal stem cell disorder characterised by <a title="Splenomegaly" href="/articles/splenomegaly">splenomegaly</a>, chronic myeloproliferation, bone marrow infiltration, and extramedullary haematopoiesis (EMH) <sup>1</sup>. It commonly presents with anaemia, palpable splenomegaly, and constitutional symptoms. Hepatosplenomegaly is a complication of significant extramedullary haematopoiesi <sup>2</sup>. Hepatomegaly and splenomegaly is seen in up to 40-70% and 90% of patients respectively <sup>3</sup>.</p><p>Splenic infarction in myelofibrosis results from a combination of infiltration of the splenic parenchyma in EMH, anaemia and increased oxygen requirements of an enlarged spleen. </p>- +<p>This case demonstrates <a href="/articles/hepatosplenomegaly">hepatosplenomegaly</a> with <a href="/articles/splenic-infarction">splenic infarction.</a></p><p><a href="/articles/primary-myelofibrosis">Myelofibrosis</a> is a clonal stem cell disorder characterised by <a href="/articles/splenomegaly">splenomegaly</a>, chronic myeloproliferation, bone marrow infiltration, and extramedullary haematopoiesis (EMH) <sup>1</sup>. It commonly presents with anaemia, palpable splenomegaly, and constitutional symptoms. Hepatosplenomegaly is a complication of significant extramedullary haematopoiesis <sup>2</sup>. Hepatomegaly and splenomegaly are seen in up to 40-70% and 90% of patients respectively <sup>3</sup>.</p><p>Splenic infarction in myelofibrosis results from a combination of infiltration of the splenic parenchyma in EMH, anaemia and increased oxygen requirements of an enlarged spleen. </p>
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