Histiocytic sarcoma is a rare malignant hematopoietic neoplasm that has been reported in association with other hematological malignancies (particularly B and T cell lymphomas).
It comprises of tumor cells derived from the monocyte/macrophage lineage.
It usually occurs in lymph nodes, skin, and the gastrointestinal tract. Occurrence in the CNS system has also been rarely reported 3.
The overall prognosis is generally poor due to rapid progression and poor response to therapy. Tumor size may be a prognostic factor.
History and etymology
It was first described by Mathé et al. in 1970.
- 1. Chalasani S, Hennick MR, Hocking WG et-al. Unusual presentation of a rare cancer: histiocytic sarcoma in the brain 16 years after treatment for acute lymphoblastic leukemia. Clin Med Res. 2013;11 (1): 31-5. doi:10.3121/cmr.2012.1092 - Free text at pubmed - Pubmed citation
- 2. Hornick JL, Jaffe ES, Fletcher CD. Extranodal histiocytic sarcoma: clinicopathologic analysis of 14 cases of a rare epithelioid malignancy. Am. J. Surg. Pathol. 2004;28 (9): 1133-44. Pubmed citation
- 3. Laviv Y, Zagzag D, Fichman-Horn S et-al. Primary central nervous system histiocytic sarcoma. Brain Tumor Pathol. 2013;30 (3): 192-5. doi:10.1007/s10014-012-0123-z - Pubmed citation