Neuritic plaques

A.Prof Frank Gaillard et al.

Neuritic plaques (also known as senile plaques) are pathological extracellular aggregates formed around a core of amyloid β peptide and are a hallmark of Alzheimer's disease

They should not be confused with neurofibrillary tangles which are intracytoplasmic.

Pathology

Neuritic plaques are extracellular and are composed of two components, a central core surrounded by a corona 1,2

The central core is composed of an aggregate of extracellular beta-pleated amyloid, composed of amyloid β Peptide. It demonstrates apple-green birefringence after Congo red stain and fluoresces after thioflavin S staining 2

The corona, which surrounds the central core, is composed of degenerating neurones (primarily axons) containing tau protein and ubiquitin.

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Article information

rID: 13477
Section: Pathology
Synonyms or Alternate Spellings:
  • Senile plaque
  • Neuritic plaque

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